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Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

The recently discovered 150-cavity (formed by loop residues 147–152, N2 numbering) adjacent to the enzymatic active site of group 1 influenza A neuraminidase (NA) has introduced a novel target for the design of next-generation NA inhibitors. However, only group 1 NAs, with the exception of the 2009...

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Detalles Bibliográficos
Autores principales:	Wu, Yan, Qin, Guangrong, Gao, Feng, Liu, Yue, Vavricka, Christopher J., Qi, Jianxun, Jiang, Hualiang, Yu, Kunqian, Gao, George F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609017/ https://www.ncbi.nlm.nih.gov/pubmed/23531861 http://dx.doi.org/10.1038/srep01551

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