UV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding

Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human γD-crystallins in the eye lens. Here we show with molecular dynamics simulations that the stability of γD-crystallin is greatly reduced by the conversion of tryptophan to kynurenine due to UV-radiation, consiste...

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Detalles Bibliográficos
Autores principales: Xia, Zhen, Yang, Zaixing, Huynh, Tien, King, Jonathan A., Zhou, Ruhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609025/
https://www.ncbi.nlm.nih.gov/pubmed/23532089
http://dx.doi.org/10.1038/srep01560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609025/
https://www.ncbi.nlm.nih.gov/pubmed/23532089
http://dx.doi.org/10.1038/srep01560

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