Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy and prevents cardiomyopathy in diabetic mice, albeit by an unknown mechanism. We hypothesized that AMPK-induced autophagy ameliorates diabetic...

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Detalles Bibliográficos
Autores principales: He, Chaoyong, Zhu, Huaiping, Li, Hongliang, Zou, Ming-Hui, Xie, Zhonglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609561/
https://www.ncbi.nlm.nih.gov/pubmed/23223177
http://dx.doi.org/10.2337/db12-0533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609561/
https://www.ncbi.nlm.nih.gov/pubmed/23223177
http://dx.doi.org/10.2337/db12-0533

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