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Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy and prevents cardiomyopathy in diabetic mice, albeit by an unknown mechanism. We hypothesized that AMPK-induced autophagy ameliorates diabetic...

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Detalles Bibliográficos
Autores principales:	He, Chaoyong, Zhu, Huaiping, Li, Hongliang, Zou, Ming-Hui, Xie, Zhonglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609561/ https://www.ncbi.nlm.nih.gov/pubmed/23223177 http://dx.doi.org/10.2337/db12-0533

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