Rab7 Silencing Prevents μ-Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy

Painful diabetic neuropathy is poorly controlled by analgesics and requires high doses of opioids, triggering side effects and reducing patient quality of life. This study investigated whether enhanced Rab7-mediated lysosomal targeting of peripheral sensory neuron μ-opioid receptors (MORs) is respon...

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Detalles Bibliográficos
Autores principales: Mousa, Shaaban A., Shaqura, Mohammed, Khalefa, Baled I., Zöllner, Christian, Schaad, Laura, Schneider, Jonas, Shippenberg, Toni S., Richter, Jan F., Hellweg, Rainer, Shakibaei, Mehdi, Schäfer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609597/
https://www.ncbi.nlm.nih.gov/pubmed/23230081
http://dx.doi.org/10.2337/db12-0590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609597/
https://www.ncbi.nlm.nih.gov/pubmed/23230081
http://dx.doi.org/10.2337/db12-0590

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