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Identification of Multiple Novel Protein Biomarkers Shed by Human Serous Ovarian Tumors into the Blood of Immunocompromised Mice and Verified in Patient Sera

The most cancer-specific biomarkers in blood are likely to be proteins shed directly by the tumor rather than less specific inflammatory or other host responses. The use of xenograft mouse models together with in-depth proteome analysis for identification of human proteins in the mouse blood is an u...

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Detalles Bibliográficos
Autores principales: Beer, Lynn A., Wang, Huan, Tang, Hsin-Yao, Cao, Zhijun, Chang-Wong, Tony, Tanyi, Janos L., Zhang, Rugang, Liu, Qin, Speicher, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609810/
https://www.ncbi.nlm.nih.gov/pubmed/23544127
http://dx.doi.org/10.1371/journal.pone.0060129