c-Cbl reduces stability of rescued ∆F508-CFTR in human airway epithelial cells: Implications for cystic fibrosis treatment

CFTR is a PKA activated Cl(-) channel expressed in the apical membrane of fluid transporting epithelia. We previously demonstrated that c-Cbl decreases CFTR stability in the plasma membrane by facilitating its endocytosis and lysosomal degradation in human airway epithelium. The most common mutation...

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Detalles Bibliográficos
Autores principales: Cihil, Kristine M., Zimnik, Andrew, Swiatecka-Urban, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609839/
https://www.ncbi.nlm.nih.gov/pubmed/23750297
http://dx.doi.org/10.4161/cib.23094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609839/
https://www.ncbi.nlm.nih.gov/pubmed/23750297
http://dx.doi.org/10.4161/cib.23094

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