Disturbance of DNA conformation by the binding of testosterone-based platinum drugs via groove-face and intercalative interactions: a molecular dynamics simulation study

BACKGROUND: To explore novel platinum-based anticancer agents that are distinct from the structure and interaction mode of the traditional cisplatin by forming the bifunctional intrastrand 1,2 GpG adduct, the monofunctional platinum + DNA adducts with extensive non-covalent interactions had been stu...

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Detalles Bibliográficos
Autores principales: Cui, Shanshan, Wang, Yan, Chen, Guangju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610147/
https://www.ncbi.nlm.nih.gov/pubmed/23517640
http://dx.doi.org/10.1186/1472-6807-13-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610147/
https://www.ncbi.nlm.nih.gov/pubmed/23517640
http://dx.doi.org/10.1186/1472-6807-13-4

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