The role of Cysteine 6.47 in class A GPCRs

BACKGROUND: The CWxP motif of transmembrane helix 6 (x: any residue) is highly conserved in class A GPCRs. Within this motif, W6.48 is a big star in the theory of the global “toggle switch” because of its key role in the activation mechanism of GPCRs upon ligand binding. With all footlights focused...

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Detalles Bibliográficos
Autores principales: Olivella, Mireia, Caltabiano, Gianluigi, Cordomí, Arnau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610275/
https://www.ncbi.nlm.nih.gov/pubmed/23497259
http://dx.doi.org/10.1186/1472-6807-13-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610275/
https://www.ncbi.nlm.nih.gov/pubmed/23497259
http://dx.doi.org/10.1186/1472-6807-13-3

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