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Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain

IP(3)R (IP(3) [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol reagents. In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as t...

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Detalles Bibliográficos
Autores principales: Khan, Samir A., Rossi, Ana M., Riley, Andrew M., Potter, Barry V. L., Taylor, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610541/
https://www.ncbi.nlm.nih.gov/pubmed/23282150
http://dx.doi.org/10.1042/BJ20121600