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Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Prion proteins can adopt self-propagating alternative conformations that account for the infectious nature of transmissible spongiform encephalopathies (TSEs) and the epigenetic inheritance of certain traits in yeast. Recent evidence suggests a similar propagation of misfolded proteins in the spread...

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Detalles Bibliográficos
Autores principales: Nussbaum-Krammer, Carmen I., Park, Kyung-Won, Li, Liming, Melki, Ronald, Morimoto, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610634/
https://www.ncbi.nlm.nih.gov/pubmed/23555277
http://dx.doi.org/10.1371/journal.pgen.1003351