DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by ‘70 bp’-repeats and telomeric-repeats, is either replaced through DNA double-strand break (DSB) repair or transcriptionally...

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Detalles Bibliográficos
Autores principales: Glover, Lucy, Alsford, Sam, Horn, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610638/
https://www.ncbi.nlm.nih.gov/pubmed/23555264
http://dx.doi.org/10.1371/journal.ppat.1003260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610638/
https://www.ncbi.nlm.nih.gov/pubmed/23555264
http://dx.doi.org/10.1371/journal.ppat.1003260

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