DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates

Biochemical and genetic studies suggest that vertebrates remove double-strand breaks (DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) pathways. While canonical NHEJ depends on the well characterized activities of DNA-dependent protein kinase (DNA-PK) and LIG4/XRCC4/XL...

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Detalles Bibliográficos
Autores principales: Paul, Katja, Wang, Minli, Mladenov, Emil, Bencsik-Theilen, Alena, Bednar, Theresa, Wu, Wenqi, Arakawa, Hiroshi, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610672/
https://www.ncbi.nlm.nih.gov/pubmed/23555685
http://dx.doi.org/10.1371/journal.pone.0059505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610672/
https://www.ncbi.nlm.nih.gov/pubmed/23555685
http://dx.doi.org/10.1371/journal.pone.0059505

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