Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice

The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer’s disease pathology. Several proteases, including Neprilysin (NEP), endothelin converting enzyme (ECE), and insulin degrading enzyme (IDE), have been shown to cleave β-amyloid peptides (Aβ). W...

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Detalles Bibliográficos
Autores principales: Carty, Nikisha, Nash, Kevin R., Brownlow, Milene, Cruite, Dana, Wilcock, Donna, Selenica, Maj-Linda B., Lee, Daniel C., Gordon, Marcia N., Morgan, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610740/
https://www.ncbi.nlm.nih.gov/pubmed/23555730
http://dx.doi.org/10.1371/journal.pone.0059626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610740/
https://www.ncbi.nlm.nih.gov/pubmed/23555730
http://dx.doi.org/10.1371/journal.pone.0059626

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