Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno-Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein

We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA encoding the heavy and light chains of this mAb were subc...

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Detalles Bibliográficos
Autores principales: Shimada, Masaru, Abe, Shinya, Takahashi, Toru, Shiozaki, Kazumasa, Okuda, Mitsue, Mizukami, Hiroaki, Klinman, Dennis M., Ozawa, Keiya, Okuda, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610755/
https://www.ncbi.nlm.nih.gov/pubmed/23555563
http://dx.doi.org/10.1371/journal.pone.0057606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610755/
https://www.ncbi.nlm.nih.gov/pubmed/23555563
http://dx.doi.org/10.1371/journal.pone.0057606

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