Cargando…

Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno-Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein

We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA encoding the heavy and light chains of this mAb were subc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shimada, Masaru, Abe, Shinya, Takahashi, Toru, Shiozaki, Kazumasa, Okuda, Mitsue, Mizukami, Hiroaki, Klinman, Dennis M., Ozawa, Keiya, Okuda, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610755/ https://www.ncbi.nlm.nih.gov/pubmed/23555563 http://dx.doi.org/10.1371/journal.pone.0057606

Ejemplares similares

The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation
por: Shimada, Masaru, et al.
Publicado: (2020)

Efficient Production of Adeno‐associated Virus Vectors Using Split‐type Helper Plasmids
por: Ogasawara, Yoji, et al.
Publicado: (1999)

Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7
por: Sato, Naoto, et al.
Publicado: (2018)

Recent Developments in Preclinical DNA Vaccination
por: Okuda, Kenji, et al.
Publicado: (2014)

Developments in Viral Vector-Based Vaccines
por: Ura, Takehiro, et al.
Publicado: (2014)

Adeno-Associated Virus as an Effective Malaria Booster Vaccine Following Adenovirus Priming
por: Yusuf, Yenni, et al.
Publicado: (2019)

Establishment of rat anti-canine DEP domain containing 1B (DEPDC1B) monoclonal antibodies
por: IGASE, Masaya, et al.
Publicado: (2020)

Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
por: Kato, Tomoaki M., et al.
Publicado: (2019)

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters
por: Shoji, Masaki, et al.
Publicado: (2012)

New vaccine production platforms used in developing SARS-CoV-2 vaccine candidates
por: Ura, Takehiro, et al.
Publicado: (2021)

Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
por: Okuda, Michiaki, et al.
Publicado: (2020)

MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
por: Press, Joan L., et al.
Publicado: (1973)

Selective Optical Control of Synaptic Transmission in the Subcortical Visual Pathway by Activation of Viral Vector-Expressed Halorhodopsin
por: Kaneda, Katsuyuki, et al.
Publicado: (2011)

Western blot data using two distinct anti-O-GlcNAc monoclonal antibodies showing unique glycosylation status on cellular proteins under 2-deoxy-d-glucose treatment
por: Okuda, Tetsuya
Publicado: (2016)

Purification of anti-glycoconjugate monoclonal antibodies using newly developed porous zirconia particles
por: Okuda, Tetsuya, et al.
Publicado: (2021)

First Nationwide Survey of 199 Patients with Amyloid A Amyloidosis in Japan
por: Okuda, Yasuaki, et al.
Publicado: (2018)

Engineering monoclonal antibodies for COVID-19 prophylaxis
por: Izadpanah, Amin, et al.
Publicado: (2022)

Preexposure and Postexposure Prophylaxis of Rabies With Adeno-Associated Virus Expressing Virus-Neutralizing Antibody in Rodent Models
por: Huang, Fei, et al.
Publicado: (2021)

Current Vaccine Platforms in Enhancing T-Cell Response
por: Ura, Takehiro, et al.
Publicado: (2022)

Isolating Human Monoclonal Antibodies Against Adeno-Associated Virus From Donors With Pre-existing Immunity
por: Giles, April R., et al.
Publicado: (2020)

Gene therapy of renal cancer using recombinant adeno-associated virus encoding human endostatin
por: Sun, Erlin, et al.
Publicado: (2018)

 Adeno-associated Virus (AAV) Dual Vector Strategies for Gene Therapy Encoding Large Transgenes
por: McClements, Michelle E., et al.
Publicado: (2017)

Minimal change nephrotic syndrome due to certolizumab pegol, an anti-tumor necrosis factor-alpha monoclonal antibody for treatment of rheumatoid arthritis
por: Sugiyama, Masafumi, et al.
Publicado: (2022)

Adeno-Viren
por: Falke, Dietrich
Publicado: (2009)

Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions
por: Kasahara, Yoshiyuki, et al.
Publicado: (2015)

The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period
por: Isoo, Noriko, et al.
Publicado: (2016)

Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown
por: Takaji, Masafumi, et al.
Publicado: (2016)

Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal
por: Murabe, Naoyuki, et al.
Publicado: (2018)

Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor
por: Uchibori, Ryosuke, et al.
Publicado: (2018)

Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain
por: Okuda, Michiaki, et al.
Publicado: (2018)

Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation
por: Urano, Yasuomi, et al.
Publicado: (2020)

Human monoclonal antibodies for prophylaxis and therapy of viral infections
por: Meulen, Jan ter, et al.
Publicado: (2006)

Chemical Visualization of an Attractant Peptide, LURE
por: Goto, Hiroaki, et al.
Publicado: (2011)

Novel strategies for Alzheimer's disease treatment: An overview of anti-amyloid beta monoclonal antibodies
por: Rygiel, Katarzyna
Publicado: (2016)

Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy
por: WANG, DONGDONG, et al.
Publicado: (2011)

A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid
por: Baatartsogt, Nemekhbayar, et al.
Publicado: (2021)

Palinopsia as an initial symptom of cerebral amyloid angiopathy-related inflammation
por: Onomura, Hitomi, et al.
Publicado: (2021)

Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method
por: Watakabe, Akiya, et al.
Publicado: (2014)

An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells
por: Miyata, Satsuki, et al.
Publicado: (2013)

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease
por: Nakamura, Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_abe45jqklkc9so69a9cu99s08i