Nuclear Phosphoinositide-Specific Phospholipase C β1 Controls Cytoplasmic CCL2 mRNA Levels in HIV-1 gp120-Stimulated Primary Human Macrophages

HIV-1 envelope glycoprotein gp120 induces, independently of infection, the release of CCL2 from macrophages. In turn, this chemokine acts as an autocrine factor enhancing viral replication. In this study, we show for the first time that phosphoinositide-specific phospholipase C (PI-PLC) is required...

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Detalles Bibliográficos
Autores principales: Spadaro, Francesca, Cecchetti, Serena, Purificato, Cristina, Sabbatucci, Michela, Podo, Franca, Ramoni, Carlo, Gessani, Sandra, Fantuzzi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610878/
https://www.ncbi.nlm.nih.gov/pubmed/23555755
http://dx.doi.org/10.1371/journal.pone.0059705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610878/
https://www.ncbi.nlm.nih.gov/pubmed/23555755
http://dx.doi.org/10.1371/journal.pone.0059705

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