Succinate Dehydrogenase Upregulation Destabilize Complex I and Limits the Lifespan of gas-1 Mutant

Many Caenorhabditis elegans mutants with dysfunctional mitochondrial electron transport chain are surprisingly long lived. Both short-lived (gas-1(fc21)) and long-lived (nuo-6(qm200)) mutants of mitochondrial complex I have been identified. However, it is not clear what are the pathways determining...

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Detalles Bibliográficos
Autores principales: Pujol, Claire, Bratic-Hench, Ivana, Sumakovic, Marija, Hench, Jürgen, Mourier, Arnaud, Baumann, Linda, Pavlenko, Victor, Trifunovic, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610896/
https://www.ncbi.nlm.nih.gov/pubmed/23555681
http://dx.doi.org/10.1371/journal.pone.0059493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610896/
https://www.ncbi.nlm.nih.gov/pubmed/23555681
http://dx.doi.org/10.1371/journal.pone.0059493

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