Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

Previously, we identified the genetic variant −241 (−/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hui-Feng, Mai, Jian-Rong, Wan, Jian-Xin, Gao, Yan-fang, Lin, Li-Na, Wang, Song-Zi, Chen, Yu-Xi, Zhang, Chen-Zi, Zhang, Yu-Jing, Xia, Bin, Liao, Kun, Lin, Yu-Chun, Lin, Zhong-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612049/
https://www.ncbi.nlm.nih.gov/pubmed/23555712
http://dx.doi.org/10.1371/journal.pone.0059574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612049/
https://www.ncbi.nlm.nih.gov/pubmed/23555712
http://dx.doi.org/10.1371/journal.pone.0059574

Ejemplares similares