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Metabolism of BYZX in Human Liver Microsomes and Cytosol: Identification of the Metabolites and Metabolic Pathways of BYZX

BYZX, [(E)-2-(4-((diethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one], belongs to a series of novel acetylcholinesterase inhibitors and has been synthesized as a new chemical entity for the treatment of Alzheimer’s disease symptoms. When incubated with human liver microsomes (HLMs),...

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Detalles Bibliográficos
Autores principales: Yu, Lushan, Jiang, Yan, Wang, Lu, Sheng, Rong, Hu, Yongzhou, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612106/
https://www.ncbi.nlm.nih.gov/pubmed/23555822
http://dx.doi.org/10.1371/journal.pone.0059882