The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice

DNA methylation plays an important role in suppressing retrotransposon activity in mammalian genomes, yet there are stages of mammalian development where global hypomethylation puts the genome at risk of retrotransposition-mediated genetic instability. Hypomethylated primordial germ cells appear to...

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Detalles Bibliográficos
Autores principales: Reichmann, Judith, Reddington, James P., Best, Diana, Read, David, Öllinger, Rupert, Meehan, Richard R., Adams, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613164/
https://www.ncbi.nlm.nih.gov/pubmed/23364048
http://dx.doi.org/10.1093/hmg/ddt029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613164/
https://www.ncbi.nlm.nih.gov/pubmed/23364048
http://dx.doi.org/10.1093/hmg/ddt029

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