Cargando…

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

Recent human trials of treatments for Alzheimer’s disease (AD) have been largely unsuccessful, raising the idea that treatment may need to be started earlier in the disease, well before cognitive symptoms appear. An early marker of AD pathology is therefore needed and it is debated as to whether amy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, Amanda L., Zinn, Raphael, Hohensinn, Barbara, Konen, Lyndsey M., Beynon, Sarah B., Tan, Richard P., Clark, Ian A., Abdipranoto, Andrea, Vissel, Bryce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613362/ https://www.ncbi.nlm.nih.gov/pubmed/23560052 http://dx.doi.org/10.1371/journal.pone.0059586

Ejemplares similares

Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Dhungana, Amolika, et al.
Publicado: (2023)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
por: Steffen, Johannes, et al.
Publicado: (2017)

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)(SL) Mice
por: Lull, Melinda E., et al.
Publicado: (2011)

Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice
por: Lanooij, Suzanne D., et al.
Publicado: (2023)

Neural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
por: Ammassari-Teule, Martine
Publicado: (2020)

Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load
por: Oroszi, Tamas, et al.
Publicado: (2023)

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease
por: Shabir, Osman, et al.
Publicado: (2020)

A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability
por: Konen, Lyndsey M., et al.
Publicado: (2020)

Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice
por: Gulbranson, Daniel R., et al.
Publicado: (2021)

Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice
por: Yang, Xiao-bo, et al.
Publicado: (2022)

Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat
por: Levit, Alexander, et al.
Publicado: (2020)

The HAPPE plus Event-Related (HAPPE+ER) software: A standardized preprocessing pipeline for event-related potential analyses
por: Monachino, A.D., et al.
Publicado: (2022)

Dissociation between complete hippocampal context memory formation and context fear acquisition
por: Leake, Jessica, et al.
Publicado: (2017)

A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease
por: Johnson, Erik C.B., et al.
Publicado: (2016)

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Carney, Rosalind S.E.
Publicado: (2019)

Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer’s Disease
por: Hendrickx, Jhana O., et al.
Publicado: (2021)

Extinction and discrimination in a Bayesian model of context fear conditioning (BaconX)
por: Krasne, Franklin B., et al.
Publicado: (2021)

Delta-secretase triggers Alzheimer’s disease pathologies in wild-type hAPP/hMAPT double transgenic mice
por: Wu, Zhourui, et al.
Publicado: (2020)

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
por: Wright, Amanda L., et al.
Publicado: (2023)

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
por: Heneka, Michael T, et al.
Publicado: (2005)

Engram Size Varies with Learning and Reflects Memory Content and Precision
por: Leake, Jessica, et al.
Publicado: (2021)

Activin A Is Essential for Neurogenesis Following Neurodegeneration
por: Abdipranoto-Cowley, Andrea, et al.
Publicado: (2009)

A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology
por: Lippi, Stephen L. P., et al.
Publicado: (2018)

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
por: Faizi, Mehrdad, et al.
Publicado: (2012)

HAPPE: A Tool for Population Haplotype Analysis and Visualization in Editable Excel Tables
por: Feng, Cong, et al.
Publicado: (2022)

Adar3 Is Involved in Learning and Memory in Mice
por: Mladenova, Dessislava, et al.
Publicado: (2018)

The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain
por: Wright, Amanda, et al.
Publicado: (2012)

Gaze patterns and brain activations in humans and marmosets in the Frith-Happé theory-of-mind animation task
por: Dureux, Audrey, et al.
Publicado: (2023)

Inflammation-sleep interface in brain disease: TNF, insulin, orexin
por: Clark, Ian A, et al.
Publicado: (2014)

A Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease
por: Clark, Ian A., et al.
Publicado: (2015)

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents
por: Clark, Ian A., et al.
Publicado: (2016)

The Inflammatory Nature of Post-surgical Delirium Predicts Benefit of Agents With Anti-TNF Effects, Such as Dexmedetomidine
por: Clark, Ian A., et al.
Publicado: (2018)

The meteorology of cytokine storms, and the clinical usefulness of this knowledge
por: Clark, Ian A., et al.
Publicado: (2017)

Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease
por: Clark, Ian A., et al.
Publicado: (2023)

Amyloid plaque formation precedes dendritic spine loss
por: Bittner, Tobias, et al.
Publicado: (2012)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE): Standardized Processing Software for Developmental and High-Artifact Data
por: Gabard-Durnam, Laurel J., et al.
Publicado: (2018)

HAPPILEE: HAPPE In Low Electrode Electroencephalography, a standardized pre-processing software for lower density recordings
por: Lopez, K.L., et al.
Publicado: (2022)

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
por: Cherry, Jonathan D., et al.
Publicado: (2015)

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
por: Morris, Gary P, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_io4magf070fnaln7457hmc6f6c