A Novel PEGylated Liposome-Encapsulated SANT75 Suppresses Tumor Growth through Inhibiting Hedgehog Signaling Pathway

The Hedgehog (Hh) pathway inhibitors have shown great promise in cancer therapeutics. SANT75, a novel compound we previously designed to specially inhibit the Smoothened (SMO) protein in the Hh pathway, has greater inhibitory potency than many of commonly used Hh inhibitors. However, preclinical stu...

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Detalles Bibliográficos
Autores principales: Yuan, Yike, Zhao, Yuwei, Xin, Shengchang, Wu, Ni, Wen, Jiaolin, Li, Song, Chen, Lijuan, Wei, Yuquan, Yang, Hanshuo, Lin, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613365/
https://www.ncbi.nlm.nih.gov/pubmed/23560085
http://dx.doi.org/10.1371/journal.pone.0060266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613365/
https://www.ncbi.nlm.nih.gov/pubmed/23560085
http://dx.doi.org/10.1371/journal.pone.0060266

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