Evolution of Hepatic Glucose Metabolism: Liver-Specific Glucokinase Deficiency Explained by Parallel Loss of the Gene for Glucokinase Regulatory Protein (GCKR)

BACKGROUND: Glucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis. However, some vertebrate species are deficient in GCK activity in t...

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Detalles Bibliográficos
Autores principales: Wang, Zhao Yang, Jin, Ling, Tan, Huanran, Irwin, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613411/
https://www.ncbi.nlm.nih.gov/pubmed/23573289
http://dx.doi.org/10.1371/journal.pone.0060896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613411/
https://www.ncbi.nlm.nih.gov/pubmed/23573289
http://dx.doi.org/10.1371/journal.pone.0060896

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