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Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor

Osteosarcoma (OS) is an aggressive bone cancer typically observed in adolescents and young adults. Metastatic relapse accounts primarily for treatment failure, and obstacles to improving cure rates include a lack of efficacious agents. Our studies show apoptosis of OS cells prepared from localized a...

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Detalles Bibliográficos
Autores principales: Fu, W, Sharma, S S, Ma, L, Chu, B, Bui, M M, Reed, D, Pledger, W J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613821/
https://www.ncbi.nlm.nih.gov/pubmed/23538447
http://dx.doi.org/10.1038/cddis.2013.101