AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia

We determined the effects of severe hypoxia (∼0.1% O(2)) on acute myeloid leukemia cells expressing the AML1/ETO oncogene. Incubation of Kasumi-1 cells in hypoxia induced growth arrest, apoptosis and reduction of AML1/ETO protein expression. The conditional expression of AML1/ETO in U937-A/E cells s...

Descripción completa

Detalles Bibliográficos
Autores principales: Barbetti, V, Tusa, I, Cipolleschi, M G, Rovida, E, Dello Sbarba, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613827/
https://www.ncbi.nlm.nih.gov/pubmed/23492767
http://dx.doi.org/10.1038/cddis.2013.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613827/
https://www.ncbi.nlm.nih.gov/pubmed/23492767
http://dx.doi.org/10.1038/cddis.2013.49

Ejemplares similares