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AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia

We determined the effects of severe hypoxia (∼0.1% O(2)) on acute myeloid leukemia cells expressing the AML1/ETO oncogene. Incubation of Kasumi-1 cells in hypoxia induced growth arrest, apoptosis and reduction of AML1/ETO protein expression. The conditional expression of AML1/ETO in U937-A/E cells s...

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Detalles Bibliográficos
Autores principales:	Barbetti, V, Tusa, I, Cipolleschi, M G, Rovida, E, Dello Sbarba, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613827/ https://www.ncbi.nlm.nih.gov/pubmed/23492767 http://dx.doi.org/10.1038/cddis.2013.49

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