Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging

To investigate the importance of the Ras-homologous GTPase Rac1 for the hepatic response to genotoxic insults and liver aging, rac1 was deleted in liver of mice by Mx1-Cre-based recombination. Knockout of rac1 caused complex changes in basal as well as doxorubicin and ionizing radiation-induced mRNA...

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Detalles Bibliográficos
Autores principales: Bopp, A, Wartlick, F, Henninger, C, Kaina, B, Fritz, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613835/
https://www.ncbi.nlm.nih.gov/pubmed/23519127
http://dx.doi.org/10.1038/cddis.2013.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613835/
https://www.ncbi.nlm.nih.gov/pubmed/23519127
http://dx.doi.org/10.1038/cddis.2013.57

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