Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS)

The catalytic subunits of all class IA phosphoinositide 3-kinases (PI3Ks) associate with identical p85-related subunits and phosphorylate PIP2 yielding PIP3, but they can vary greatly in the signaling pathways in which they participate. The binding of the p85 subunit to the p110 catalytic subunits i...

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Detalles Bibliográficos
Autores principales: Burke, John E., Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613897/
https://www.ncbi.nlm.nih.gov/pubmed/23194976
http://dx.doi.org/10.1016/j.jbior.2012.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613897/
https://www.ncbi.nlm.nih.gov/pubmed/23194976
http://dx.doi.org/10.1016/j.jbior.2012.09.005

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