Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1

The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a co...

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Detalles Bibliográficos
Autores principales: Sanjuán, Rafael, Nebot, Miguel R., Peris, Joan B., Alcamí, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614509/
https://www.ncbi.nlm.nih.gov/pubmed/23565057
http://dx.doi.org/10.1371/journal.pbio.1001523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614509/
https://www.ncbi.nlm.nih.gov/pubmed/23565057
http://dx.doi.org/10.1371/journal.pbio.1001523

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