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Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a co...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614509/ https://www.ncbi.nlm.nih.gov/pubmed/23565057 http://dx.doi.org/10.1371/journal.pbio.1001523 |