PARP Inhibition Sensitizes to Low Dose-Rate Radiation TMPRSS2-ERG Fusion Gene-Expressing and PTEN-Deficient Prostate Cancer Cells

Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is impaired. Poly (ADP-ribose) polymerase (PARP) inhibitors were found to be “synthetic lethal” in cells deficient in BRCA1 and BRCA2 that impair homologous recombination. Ho...

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Detalles Bibliográficos
Autores principales: Chatterjee, Payel, Choudhary, Gaurav S., Sharma, Arishya, Singh, Kamini, Heston, Warren D., Ciezki, Jay, Klein, Eric A., Almasan, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614551/
https://www.ncbi.nlm.nih.gov/pubmed/23565244
http://dx.doi.org/10.1371/journal.pone.0060408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614551/
https://www.ncbi.nlm.nih.gov/pubmed/23565244
http://dx.doi.org/10.1371/journal.pone.0060408

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