PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+Gr1lo monocytic lineage cells and CD11b+Gr1hi granulocytic lineage cells are recruited from the circulation by tumor-derived chemoattractants,...

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Detalles Bibliográficos
Autores principales: Schmid, Michael C., Franco, Irene, Kang, Sang Won, Hirsch, Emilio, Quilliam, Lawrence A., Varner, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614555/
https://www.ncbi.nlm.nih.gov/pubmed/23565202
http://dx.doi.org/10.1371/journal.pone.0060226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614555/
https://www.ncbi.nlm.nih.gov/pubmed/23565202
http://dx.doi.org/10.1371/journal.pone.0060226

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