Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung

The Signal Transducer and Activator of Transcription 5 (Stat5) plays a significant role in normal hematopoiesis and a variety of hematopoietic malignancies. Deficiency in Stat5 causes impaired cytokine-mediated proliferation and survival of progenitors and their differentiated descendants along majo...

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Detalles Bibliográficos
Autores principales: Lin, Wan-chi, Schmidt, Jeffrey W., Creamer, Bradley A., Triplett, Aleata A., Wagner, Kay-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614894/
https://www.ncbi.nlm.nih.gov/pubmed/23565285
http://dx.doi.org/10.1371/journal.pone.0060902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614894/
https://www.ncbi.nlm.nih.gov/pubmed/23565285
http://dx.doi.org/10.1371/journal.pone.0060902

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