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Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues
CTLA-4 is an essential inhibitor of T cell immune responses. At steady state, most CTLA-4 resides in intracellular compartments due to constitutive internalisation mediated via a tyrosine based endocytic motif (YVKM) within the cytoplasmic domain. This domain is highly conserved in mammals suggestin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614947/ https://www.ncbi.nlm.nih.gov/pubmed/23565286 http://dx.doi.org/10.1371/journal.pone.0060903 |