Conjugation of Cholesterol to HIV-1 Fusion Inhibitor C34 Increases Peptide-Membrane Interactions Potentiating Its Action

Recently, the covalent binding of a cholesterol moiety to a classical HIV-1 fusion inhibitor peptide, C34, was shown to potentiate its antiviral activity. Our purpose was to evaluate the interaction of cholesterol-conjugated and native C34 with membrane model systems and human blood cells to underst...

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Detalles Bibliográficos
Autores principales: Hollmann, Axel, Matos, Pedro M., Augusto, Marcelo T., Castanho, Miguel A. R. B., Santos, Nuno C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614957/
https://www.ncbi.nlm.nih.gov/pubmed/23565220
http://dx.doi.org/10.1371/journal.pone.0060302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614957/
https://www.ncbi.nlm.nih.gov/pubmed/23565220
http://dx.doi.org/10.1371/journal.pone.0060302

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