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Conjugation of Cholesterol to HIV-1 Fusion Inhibitor C34 Increases Peptide-Membrane Interactions Potentiating Its Action
Recently, the covalent binding of a cholesterol moiety to a classical HIV-1 fusion inhibitor peptide, C34, was shown to potentiate its antiviral activity. Our purpose was to evaluate the interaction of cholesterol-conjugated and native C34 with membrane model systems and human blood cells to underst...
Autores principales: | Hollmann, Axel, Matos, Pedro M., Augusto, Marcelo T., Castanho, Miguel A. R. B., Santos, Nuno C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614957/ https://www.ncbi.nlm.nih.gov/pubmed/23565220 http://dx.doi.org/10.1371/journal.pone.0060302 |
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