Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK

As the second essential enzyme of the folate biosynthetic pathway, the potential antimicrobial target, HPPK (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase), catalyzes the Mg(2+-)dependant transfer of pyrophosphate from the cofactor (ATP) to the substrate, 6-hydroxymethyl-7,8-dihydropterin. Rec...

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Detalles Bibliográficos
Autores principales: Chhabra, Sandeep, Barlow, Nicholas, Dolezal, Olan, Hattarki, Meghan K., Newman, Janet, Peat, Thomas S., Graham, Bim, Swarbrick, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614987/
https://www.ncbi.nlm.nih.gov/pubmed/23565155
http://dx.doi.org/10.1371/journal.pone.0059535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614987/
https://www.ncbi.nlm.nih.gov/pubmed/23565155
http://dx.doi.org/10.1371/journal.pone.0059535

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