Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 m...

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Autores principales: Enns, Caroline A., Ahmed, Riffat, Wang, Jiaohong, Ueno, Akiko, Worthen, Christal, Tsukamoto, Hidekazu, Zhang, An-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615098/
https://www.ncbi.nlm.nih.gov/pubmed/23565256
http://dx.doi.org/10.1371/journal.pone.0060534
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author Enns, Caroline A.
Ahmed, Riffat
Wang, Jiaohong
Ueno, Akiko
Worthen, Christal
Tsukamoto, Hidekazu
Zhang, An-Sheng
author_facet Enns, Caroline A.
Ahmed, Riffat
Wang, Jiaohong
Ueno, Akiko
Worthen, Christal
Tsukamoto, Hidekazu
Zhang, An-Sheng
author_sort Enns, Caroline A.
collection PubMed
description Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 mRNA. Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver. Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes. These observations suggest an important role of the non-parenchymal liver cells in regulating iron-homeostasis by acting as a source of Bmp6.
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spelling pubmed-36150982013-04-05 Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway Enns, Caroline A. Ahmed, Riffat Wang, Jiaohong Ueno, Akiko Worthen, Christal Tsukamoto, Hidekazu Zhang, An-Sheng PLoS One Research Article Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 mRNA. Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver. Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes. These observations suggest an important role of the non-parenchymal liver cells in regulating iron-homeostasis by acting as a source of Bmp6. Public Library of Science 2013-04-02 /pmc/articles/PMC3615098/ /pubmed/23565256 http://dx.doi.org/10.1371/journal.pone.0060534 Text en © 2013 Enns et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Enns, Caroline A.
Ahmed, Riffat
Wang, Jiaohong
Ueno, Akiko
Worthen, Christal
Tsukamoto, Hidekazu
Zhang, An-Sheng
Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title_full Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title_fullStr Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title_full_unstemmed Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title_short Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway
title_sort increased iron loading induces bmp6 expression in the non-parenchymal cells of the liver independent of the bmp-signaling pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615098/
https://www.ncbi.nlm.nih.gov/pubmed/23565256
http://dx.doi.org/10.1371/journal.pone.0060534
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