Cargando…

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Enns, Caroline A., Ahmed, Riffat, Wang, Jiaohong, Ueno, Akiko, Worthen, Christal, Tsukamoto, Hidekazu, Zhang, An-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615098/ https://www.ncbi.nlm.nih.gov/pubmed/23565256 http://dx.doi.org/10.1371/journal.pone.0060534

Ejemplares similares

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body
por: Worthen, Christal A., et al.
Publicado: (2014)

Bmp6 Expression Can Be Regulated Independently of Liver Iron in Mice
por: Zhang, Zhuzhen, et al.
Publicado: (2014)

Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?
por: Rausa, Marco, et al.
Publicado: (2015)

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
por: Berasi, Stephen P, et al.
Publicado: (2011)

BMP6 Mediates BMP2-Increased Human Trophoblast Invasion
por: Deng, Jianye, et al.
Publicado: (2021)

BMP10 functions independently from BMP9 for the development of a proper arteriovenous network
por: Choi, Hyunwoo, et al.
Publicado: (2022)

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway
por: Kopf, Jessica, et al.
Publicado: (2012)

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
por: Bandyopadhyay, Amitabha, et al.
Publicado: (2006)

Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage
por: Mizoguchi, Takamasa, et al.
Publicado: (2023)

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
por: Kim, Hyung-Seok, et al.
Publicado: (2019)

Potential Roles of BMP9 in Liver Fibrosis
por: Bi, Jianjun, et al.
Publicado: (2014)

BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration
por: Herrera, Blanca, et al.
Publicado: (2017)

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis
por: Core, Amanda B., et al.
Publicado: (2014)

The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo
por: Traeger, Lisa, et al.
Publicado: (2018)

Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton
por: Kochanowska, Iwona, et al.
Publicado: (2007)

Bmp2, Bmp4 and Bmp7 Are Co-Required in the Mouse AER for Normal Digit Patterning but Not Limb Outgrowth
por: Choi, Kyung-Suk, et al.
Publicado: (2012)

The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands
por: Ramel, Marie-Christine, et al.
Publicado: (2013)

Agrin Binds BMP2, BMP4 and TGFβ1
por: Bányai, László, et al.
Publicado: (2010)

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia
por: Tillet, Emmanuelle, et al.
Publicado: (2015)

ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis
por: Perron, Jeanette C., et al.
Publicado: (2009)

Specification of BMP Signaling
por: Nickel, Joachim, et al.
Publicado: (2019)

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
por: Kobielak, Krzysztof, et al.
Publicado: (2003)

Runx3 regulates iron metabolism via modulation of BMP signalling
por: Kim, Hyun‐Yi, et al.
Publicado: (2021)

Implications of BMP9/10 for patients with liver cirrhosis
por: Ji, Dong, et al.
Publicado: (2020)

Asymmetric paralog evolution between the “cryptic” gene Bmp16 and its well-studied sister genes Bmp2 and Bmp4
por: Feiner, Nathalie, et al.
Publicado: (2019)

BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin
por: Gibert, Yann, et al.
Publicado: (2011)

Loading BMP-2 on nanostructured hydroxyapatite microspheres for rapid bone regeneration
por: Zhou, Panyu, et al.
Publicado: (2018)

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells
por: Valera, Elvira, et al.
Publicado: (2010)

Assessment of plasma BMP-2, BMP-7, BMP-10, vitamin D, and TGF β1 in simple fractures among Sudanese patients
por: Ali, Amin Ahmed, et al.
Publicado: (2021)

CK2.3, a Mimetic Peptide of the BMP Type I Receptor, Increases Activity in Osteoblasts over BMP2
por: Weidner, Hilary, et al.
Publicado: (2019)

Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling
por: Posa, Francesca, et al.
Publicado: (2019)

Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers
por: Gipson, Gregory R., et al.
Publicado: (2023)

C. elegans SMOC-1 interacts with both BMP and glypican to regulate BMP signaling
por: DeGroot, Melisa S., et al.
Publicado: (2023)

Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients
por: Dunmore, Benjamin J., et al.
Publicado: (2023)

SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans
por: DeGroot, Melisa S., et al.
Publicado: (2023)

Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels
por: Vasilyev, Andrey Vyacheslavovich, et al.
Publicado: (2021)

Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression
por: Kawai, Mariko, et al.
Publicado: (2006)

Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development
por: Dong, Xiao-Ru, et al.
Publicado: (2022)

Iron-dependent BMP6 Regulation in Liver Sinusoidal Endothelial Cells Is Instructed by Hepatocyte-derived Secretory Signals
por: Colucci, Silvia, et al.
Publicado: (2022)

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
por: Goh, Justin B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ka4j2s4vovh9s5of041mhqci65