IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

Many cancers arise at sites of infection and inflammation. Cellular senescence, a permanent state of cell cycle arrest that provides a barrier against tumorigenesis, is accompanied by elevated proinflammatory cytokines such as IL1, IL6, IL8 and TNFα. Here we demonstrate that media conditioned by cel...

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Detalles Bibliográficos
Autores principales: Hubackova, Sona, Krejcikova, Katerina, Bartek, Jiri, Hodny, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615160/
https://www.ncbi.nlm.nih.gov/pubmed/23385065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615160/
https://www.ncbi.nlm.nih.gov/pubmed/23385065

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