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Genome-wide mechanisms of Smad binding

A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β fami...

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Detalles Bibliográficos
Autores principales: Morikawa, M, Koinuma, D, Miyazono, K, Heldin, C-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615190/
https://www.ncbi.nlm.nih.gov/pubmed/22614010
http://dx.doi.org/10.1038/onc.2012.191