A network of genes connects polyglutamine toxicity to ploidy control in yeast

Neurodegeneration is linked to protein aggregation in several human disorders. In Huntington’s disease, the length of a polyglutamine stretch in Huntingtin is correlated to neuronal death. Here we utilize a model based on glutamine stretches of 0, 30 or 56 residues in Saccharomyces cerevisiae to und...

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Detalles Bibliográficos
Autores principales: Kaiser, Christoph J.O., Grötzinger, Stefan W., Eckl, Julia M., Papsdorf, Katharina, Jordan, Stefan, Richter, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615466/
https://www.ncbi.nlm.nih.gov/pubmed/23481379
http://dx.doi.org/10.1038/ncomms2575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615466/
https://www.ncbi.nlm.nih.gov/pubmed/23481379
http://dx.doi.org/10.1038/ncomms2575

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