Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

Vitamin B12 (cobalamin) is a key determinant of S-adenosyl methionine (SAM)-dependent epigenomic cellular regulations related to methylation/acetylation and its deficiency produces neurodegenerative disorders by elusive mechanisms. Sirtuin 1 deacetylase (SIRT1) triggers cell response to nutritional...

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Detalles Bibliográficos
Autores principales: Ghemrawi, R, Pooya, S, Lorentz, S, Gauchotte, G, Arnold, C, Gueant, J-L, Battaglia-Hsu, S-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615730/
https://www.ncbi.nlm.nih.gov/pubmed/23519122
http://dx.doi.org/10.1038/cddis.2013.69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615730/
https://www.ncbi.nlm.nih.gov/pubmed/23519122
http://dx.doi.org/10.1038/cddis.2013.69

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