In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles...

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Detalles Bibliográficos
Autores principales: Kim, Taejin, Afonin, Kirill A., Viard, Mathias, Koyfman, Alexey Y, Sparks, Selene, Heldman, Eliahu, Grinberg, Sarina, Linder, Charles, Blumenthal, Robert P, Shapiro, Bruce A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615820/
https://www.ncbi.nlm.nih.gov/pubmed/23511334
http://dx.doi.org/10.1038/mtna.2013.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615820/
https://www.ncbi.nlm.nih.gov/pubmed/23511334
http://dx.doi.org/10.1038/mtna.2013.5

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