EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells

Natural killer (NK) cells are highly specialized effectors of the innate immune system that hold promise for adoptive cancer immunotherapy. Their cell killing activity is primarily mediated by the pro-apoptotic serine protease granzyme B (GrB), which enters targets cells with the help of the pore-fo...

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Detalles Bibliográficos
Autores principales: Oberoi, Pranav, Jabulowsky, Robert A., Bähr-Mahmud, Hayat, Wels, Winfried S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616035/
https://www.ncbi.nlm.nih.gov/pubmed/23573299
http://dx.doi.org/10.1371/journal.pone.0061267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616035/
https://www.ncbi.nlm.nih.gov/pubmed/23573299
http://dx.doi.org/10.1371/journal.pone.0061267

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