Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs

Dog models with spontaneously occurring mutations in retinal dystrophy genes are an invaluable resource for preclinical development of retinal gene therapy. Adeno-associated virus (AAV) vectors have been most successful; to target the outer retina and RPE they are delivered by subretinal injection,...

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Detalles Bibliográficos
Autores principales: Bruewer, Ashlee R., Mowat, Freya M., Bartoe, Joshua T., Boye, Sanford L., Hauswirth, William W., Petersen-Jones, Simon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616166/
https://www.ncbi.nlm.nih.gov/pubmed/23560080
http://dx.doi.org/10.1371/journal.pone.0060218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616166/
https://www.ncbi.nlm.nih.gov/pubmed/23560080
http://dx.doi.org/10.1371/journal.pone.0060218

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