Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development

FBXW7 acts as a tumor suppressor in numerous types of human cancers through ubiquitination of different oncoproteins including mTOR. However, how the mutation/loss of Fbxw7 results in tumor development remains largely unknown. Here we report that downregulation of mTOR by radiation is Fbxw7-dependen...

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Detalles Bibliográficos
Autores principales: Liu, Yueyong, Huang, Yurong, Wang, Zeran, Huang, Yong, Li, Xiaohua, Louie, Alexander, Wei, Guangwei, Mao, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616198/
https://www.ncbi.nlm.nih.gov/pubmed/23454868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616198/
https://www.ncbi.nlm.nih.gov/pubmed/23454868

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