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4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats

The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at...

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Autores principales: Yu, Wook-Joon, Lee, In-Chul, Lee, Jinsoo, Lee, Sang-Min, Kim, Sung-Hwan, Baek, Hyung-Seon, Moon, Changjong, Kim, Sung-Ho, Chung, Yong-Hyun, Kim, Jong-Choon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616209/
https://www.ncbi.nlm.nih.gov/pubmed/23573108
http://dx.doi.org/10.5625/lar.2013.29.1.48
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author Yu, Wook-Joon
Lee, In-Chul
Lee, Jinsoo
Lee, Sang-Min
Kim, Sung-Hwan
Baek, Hyung-Seon
Moon, Changjong
Kim, Sung-Ho
Chung, Yong-Hyun
Kim, Jong-Choon
author_facet Yu, Wook-Joon
Lee, In-Chul
Lee, Jinsoo
Lee, Sang-Min
Kim, Sung-Hwan
Baek, Hyung-Seon
Moon, Changjong
Kim, Sung-Ho
Chung, Yong-Hyun
Kim, Jong-Choon
author_sort Yu, Wook-Joon
collection PubMed
description The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weight, hematology, serum biochemistry, gross findings, and organ weight were examined. At 1,000 mg/kg/day, an increase in the clinical signs and weights of the liver and kidneys was observed in the male rats. Serum biochemical investigations revealed an increase in alanine aminotransferase, alkaline phosphatase, total cholesterol, total bilirubin, phospholipids, blood urea nitrogen, and gamma glutamyl transferase levels. There were no treatment-related adverse effects in the low and middle-dose groups. In the present experimental conditions, the target organs were determined to be liver and kidney. The no-observed-adverse-effect level was considered to be 300 mg/kg/day in rats.
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spelling pubmed-36162092013-04-09 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats Yu, Wook-Joon Lee, In-Chul Lee, Jinsoo Lee, Sang-Min Kim, Sung-Hwan Baek, Hyung-Seon Moon, Changjong Kim, Sung-Ho Chung, Yong-Hyun Kim, Jong-Choon Lab Anim Res Original Article The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weight, hematology, serum biochemistry, gross findings, and organ weight were examined. At 1,000 mg/kg/day, an increase in the clinical signs and weights of the liver and kidneys was observed in the male rats. Serum biochemical investigations revealed an increase in alanine aminotransferase, alkaline phosphatase, total cholesterol, total bilirubin, phospholipids, blood urea nitrogen, and gamma glutamyl transferase levels. There were no treatment-related adverse effects in the low and middle-dose groups. In the present experimental conditions, the target organs were determined to be liver and kidney. The no-observed-adverse-effect level was considered to be 300 mg/kg/day in rats. Korean Association for Laboratory Animal Science 2013-03 2013-03-25 /pmc/articles/PMC3616209/ /pubmed/23573108 http://dx.doi.org/10.5625/lar.2013.29.1.48 Text en Copyright © 2013 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yu, Wook-Joon
Lee, In-Chul
Lee, Jinsoo
Lee, Sang-Min
Kim, Sung-Hwan
Baek, Hyung-Seon
Moon, Changjong
Kim, Sung-Ho
Chung, Yong-Hyun
Kim, Jong-Choon
4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title_full 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title_fullStr 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title_full_unstemmed 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title_short 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
title_sort 4-week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616209/
https://www.ncbi.nlm.nih.gov/pubmed/23573108
http://dx.doi.org/10.5625/lar.2013.29.1.48
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