GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...

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Detalles Bibliográficos
Autores principales: Zekri, Latifa, Kuzuoğlu-Öztürk, Duygu, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616289/
https://www.ncbi.nlm.nih.gov/pubmed/23463101
http://dx.doi.org/10.1038/emboj.2013.44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616289/
https://www.ncbi.nlm.nih.gov/pubmed/23463101
http://dx.doi.org/10.1038/emboj.2013.44

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